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April 3, 2026Brain and Behavior0 citationsOpen Access

Anshen Jieyu Decoction: A Promising Remedy for Depression via AKT/mTOR Pathway Modulation in CUMS Rats

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ZLZhen LiZJZijun JiZZZehao Zhang

Key Points

  • This research investigates the effects of Anshen Jieyu Decoction on depression and its underlying mechanisms in a rat model of chronic stress.
  • Utilized CUMS (chronic unpredictable mild stress) model in rats to induce depression-like behavior.
  • Administered Anshen Jieyu Decoction to evaluate its effects on behavioral deficits.
  • Assessed biochemical markers including AKT and mTOR phosphorylation and HPA axis activity.
  • Anshen Jieyu Decoction improved behavioral deficits in CUMS-induced rats.
  • Treatment reduced hyperactivity of the hypothalamic-pituitary-adrenal axis.
  • Increased phosphorylation of AKT and mTOR was observed, indicating pathway activation.
  • Neuronal damage in hippocampus was significantly reduced.

Abstract

ASJYD ameliorates CUMS-induced behavioral deficits, reduces hypothalamic-pituitary-adrenal axis hyperactivity, is associated with increased phosphorylation of AKT and mTOR, and protects against hippocampal neuronal damage.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69cf5e5f5a333a821460cbb7https://doi.org/10.1002/brb3.71380
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