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April 3, 2026Circulation Reports0 citationsOpen Access

Relationship of Depression With Incident Cardiovascular Disease in Individuals With Chronic Kidney Disease

DKDaiki KuroyanagiHKHidehiro KanekoYSYuta Suzuki

Key Points

  • This research aims to explore how depression affects the likelihood of developing cardiovascular disease in individuals with chronic kidney disease.
  • Examined the relationship between depression and cardiovascular disease in chronic kidney disease patients.

Structured PICO

Does depression increase the risk of incident cardiovascular disease in individuals with chronic kidney disease?

P
Population
281,961 individuals with chronic kidney disease (eGFR <60 mL/min/1.73 m2 or proteinuria ≥1+), median age 68, 47.8% male, from the DeSC database in Japan. Excluded: prior history of cardiovascular disease, kidney replacement therapy, and missing data on smoking or physical inactivity.
I
Intervention
Presence of depression (diagnosed before initial health check-up using ICD-10 codes)
C
Comparator
Absence of depression
O
Outcome
Composite endpoint including ischemic heart disease, stroke, and heart failurecomposite

Depression is independently associated with a 36% increased risk of incident cardiovascular disease among individuals with chronic kidney disease, regardless of baseline kidney function.

Limitations

  • Accuracy of recorded diagnoses of depression remains uncertain due to inherent limitations in claims databases.
  • Impossible to eliminate all potential influence of unmeasured confounding factors such as socioeconomic status.
  • Generalizability of findings to other races and regions needs validation, as the dataset is from Japan.

Abstract

Background: Depression is common in patients with chronic kidney disease (CKD) and known to be associated with a greater risk of developing cardiovascular disease (CVD). However, it is uncertain whether, and to what extent, depression influences the incidence of CVD among individuals with CKD.

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Cite This Study

Kuroyanagi et al. (2026) studied this question.

synapsesocial.com/papers/69cf5e865a333a821460cf66https://doi.org/10.1253/circrep.cr-25-0262
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronic kidney disease is associated with incident depression requiring treatment: a retrospective cohort study2025 · 8 citations
  2. 2Association between incident depression and clinical outcomes in patients with chronic kidney disease2023 · 38 citations
  3. 3Depression in CKD: Understanding the Mechanisms of Disease2018 · 30 citations
  4. 4Depression and all-cause and cardiovascular disease mortality among adults with and without moderate chronic kidney disease: a cohort study2022
  5. 5Increased Risk of Incident Chronic Kidney Disease, Cardiovascular Disease, and Mortality in Patients With Diabetes With Comorbid Depression2016 · 104 citations