PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
April 3, 2026Angewandte Chemie International Edition0 citations

Inside Front Cover: A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub‐Quantal Exocytosis in Living Neurons and Organoids

View Full Paper
WZWanying ZhuYZYufan ZhangHYHanwen Yu

Key Points

  • The study aims to develop a nanosensor to monitor acetylcholine dynamics in living neurons with high precision.
  • Introduced Ti3C2Tx MXene/enzyme-functionalized nanosensor platform.
  • Achieved high spatiotemporal resolution for neurotransmitter analysis.
  • Inserted the nanosensor into living neurons to monitor single-vesicle dynamics.
  • Successfully monitored single-vesicle acetylcholine storage.
  • Tracked exocytosis dynamics in real time.
  • Demonstrated breakthroughs in technical barriers for neurotransmitter analysis.

Abstract

In the Research Article (e20854), Wanying Zhu, Xing Guo, Yan Liu, and co-workers introduce a novel Ti3C2Tx MXene/enzyme-functionalized (M@E@CF) nanosensor platform that breaks through long-standing technical barriers in neurotransmitter analysis: it enables high spatiotemporal resolution, in situ quantitative monitoring of single-vesicle acetylcholine (ACh) storage and exocytosis dynamics—by precisely inserting into living neurons.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/69cf5ecb5a333a821460d734https://doi.org/10.1002/anie.2026-m2603023100
Ask AI
Helpful
Bookmark
Share
View Full Paper