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April 3, 2026JAMA Surgery

Small Bites vs Large Bites for Closure of Abdominal Midline Incisions

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Authors

RBR. van den BergSESarah van EgmondFSFokko Smits

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Overview

Multicenter randomized trial evaluates incisional hernia incidence after different closure techniques in abdominal surgery, highlighting long-term benefit of small bites.

Key Points

  • The study aims to evaluate the incidence of incisional hernias 13 years after midline laparotomy using different closure techniques.
  • Multicenter, double-blind randomized trial design done between October 2009 and March 2012.
  • 559 patients undergoing elective midline laparotomy were randomized to small-bites or large-bites closure.
  • Primary outcome was cumulative incidence of incisional hernia analyzed with time-to-event methods.
  • At 13 years, incisional hernia cumulative incidence was 34% in the small-bites group and 49% in the large-bites group.
  • Hernia widths greater than 20 mm were 17% for small-bites and 34% for large-bites (hazard ratio 0.36).
  • Smaller hernia sizes were observed in the small-bites group at final follow-up (mean 25 mm vs 43 mm; P = .02).

Cite This Study

Berg et al. (2026) studied this question.

synapsesocial.com/papers/69cf5f005a333a821460dd42https://doi.org/10.1001/jamasurg.2026.0618
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Small-Bites Closure in Emergency Laparotomy—Reply2026
  2. 2Small-Bite Versus Large-Bite Closure for the Prevention of Incisional Hernia: A Meta-Analysis2026
  3. 3Impact of small-bite (5 mm) fascial closure on the incidence of incisional hernia following open colorectal cancer surgery: randomized clinical trial2024 · 8 citations
  4. 4SP6.10 - The Inevitable Way Ahead: “Small Bites” Closure For Extraction Sites In Colorectal Resections2024
  5. 5Reduced Fascial Dehiscence with Combined Small-and-Large Technique Compared to Small-Bite Technique in Emergency Midline Laparotomy: A Retrospective Study2026