Recent Advances in Asymmetric Catalytic Synthesis of P-Stereogenic Compounds

Key Points

• The aim is to outline recent advancements in the synthesis of P-stereogenic organophosphorus compounds.
• Review of advancements from 2020 to 2025
• Focus on enantiospecific transformations of P-stereogenic precursors
• Examination of catalytic desymmetrization of prochiral P compounds
• Analysis of dynamic kinetic resolution of racemic substrates
• Overview of asymmetric oxidation of P(III) compounds
• Significant progress noted in the construction of P-stereogenic centers
• Enhanced efficiency in enantiospecific transformations
• Development of new catalytic strategies for prochiral P compounds
• Improved methods for kinetic resolution of racemic substrates
• Innovative approaches to asymmetric oxidation of P(III) compounds

Abstract