Vascular diseases, such as atherosclerosis, thrombosis, and aneurysms, can lead to life‐threatening medical events. Conventional catheter‐ or guidewire‐based interventional devices often struggle to navigate through highly tortuous vasculature. The recently developed multifunctional magnetic milli‐spinner offers a promising wireless solution by integrating a central through‐hole and side slits into a cylindrical body with helical fins, enabling rapid and stable navigation for clot debulking, targeted drug delivery, and aneurysm treatment. Here, we combine computational fluid dynamics simulations with experimental validation to optimize the milli‐spinner's structural design for high‐velocity propulsion and high‐efficiency clot debulking in tubular flow environments. By systematically investigating the effects of through‐hole radius, fin number, fin helical angle, and slit dimension on propulsion performance, the optimized milli‐spinner achieves swimming velocities of 55 cm/s (≈175 body lengths/s) in saline water and 44 cm/s (≈140 body lengths/s) in a fluid with viscosity (3.5 mPa·s) comparable to that of arterial blood at high shear rates, far exceeding existing untethered magnetic robots in tubular environments (<80 body lengths/s). This exceptional velocity enables stable upstream operation against strong physiological flows representative of major arteries and veins, establishing the milli‐spinner as a robust untethered navigation platform for operation in high‐flow, tortuous vasculature.
Lu et al. (2026) studied this question.