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April 5, 2026Nutrition and Diabetes0 citationsOpen Access

Multi-cohort analysis of metagenome for type 2 diabetes identified universal gut microbiota signatures across populations

YDYing DongMWMinjie WangXZXinyu Zhou

Key Points

  • The aim is to identify and analyze gut microbiota profiles associated with type 2 diabetes across different populations.
  • Multi-cohort analysis of diverse populations
  • Characterization of gut microbial profiles
  • Comparison of microbiota signatures in type 2 diabetes patients
  • Identified reproducible gut commensal bacteria profiles in T2D patients
  • Universal microbiome signatures were consistent across populations
  • Insights can aid in disease prevention and diagnostic methods

Abstract

Our results elucidated reproducible profiles of gut commensal bacteria in patients with T2D, which are robust across populations. Identifying the universal gut microbiome signatures of T2D in heterogeneous cohorts offers valuable insights for understanding disease development and is crucial for prevention and diagnosis across diverse populations.

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Cite This Study

Dong et al. (2026) studied this question.

synapsesocial.com/papers/69d1fb20a79560c99a0a1817https://doi.org/10.1038/s41387-026-00418-w
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