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April 5, 2026Frontiers in Cardiovascular MedicineOpen Access

Pathogenic role of mitochondrial DNA mutations in heart failure: clinical features, mechanisms, and therapeutic prospects

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Authors

MNM NiAZAijia ZhengHZHang Zheng

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Overview

Review summarizes the role of mitochondrial DNA mutations in heart failure, indicating potential therapeutic strategies.

Key Points

  • This review aims to elucidate the pathogenic mechanisms of mitochondrial DNA (mtDNA) mutations in heart failure (HF).
  • Comprehensive literature review of studies on mtDNA mutations related to heart failure.
  • Analysis of the effects of mtDNA mutations on oxidative phosphorylation and ATP production.
  • Integration of findings on mitochondrial dysfunction with immune inflammatory pathways and myocardial remodeling.
  • Mitochondrial DNA mutations significantly influence energy metabolism and heart function.
  • Reactive oxygen species accumulation is linked to mtDNA mutations and heart failure progression.
  • Diverse clinical phenotypes of heart failure are associated with variations in mtDNA mutation load and heteroplasmy.

Cite This Study

Ni et al. (2026) studied this question.

synapsesocial.com/papers/69d1fb20a79560c99a0a181fhttps://doi.org/10.3389/fcvm.2026.1781927
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