This comprehensive review characterizes severe cutaneous reactions in prostate cancer patients treated with apalutamide, suggesting effective management strategies.
Key Points
This review aims to characterize severe cutaneous adverse reactions associated with apalutamide and summarize management strategies based on case reports.
Systematic search of PubMed, Europe PMC, and CNKI for reported cases of SCARs related to apalutamide.
Analysis of 18 identified cases of severe cutaneous reactions.
Review of clinical characteristics and treatment protocols for reported cases.
Identified 3 cases of DRESS, 14 cases of SJS/TEN, and 1 case of AGEP linked to apalutamide.
Most common SCAR reported was SJS/TEN; median onset time was 39.5 days.
Predominance of cases occurred in East Asia; proposed therapeutic strategies based on literature review.