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April 5, 2026Clinical Breast CancerOpen Access

Patterns of disease progression in advanced breast cancer patients treated with Cyclin D kinase 4/6 inhibitors: Prognostic and therapeutic implications

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Authors

SKSudhir KumarNPNeha PathakRPRossanna C. Pezo

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Overview

Retrospective study reveals progression patterns in advanced breast cancer, suggesting treatment strategies.

Key Points

  • This research aims to classify patterns of disease progression in patients with HR+/HER2- advanced breast cancer treated with CDK4/6 inhibitors and evaluate their prognostic significance.
  • Analyzed real-world data from 151 patients with advanced breast cancer
  • Classified patients into four disease progression patterns based on ESTRO/EORTC consensus
  • Evaluated 1-year progression-free survival (PFS) and 3-year overall survival (OS) rates
  • Identified four patterns of progression: repeat oligoprogression (22%), induced oligoprogression (9%), repeat polyprogression (61%), and diffuse polyprogression (8%)
  • Significant differences in 1-year PFS and 3-year OS among the identified progression patterns
  • Continuation of CDK4/6 inhibitors beyond induced oligoprogression did not worsen patient outcomes

Cite This Study

Kumar et al. (2026) studied this question.

synapsesocial.com/papers/69d1fc28a79560c99a0a1cf7https://doi.org/10.1016/j.clbc.2026.04.001
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