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April 5, 2026Cancer Research0 citations

Integrative Analysis Identifies Carcinogenic Effects of 1,4-Phenylenediamine in Hepatocellular...

Abstract 4138: Integrative computational and experimental analysis identifies carcinogenic effects of 1,4-Phenylenediamine in hepatocellular carcinoma via PI3K/AKT-MAPK and JAK/STAT signaling pathway

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Authors

LBLiuxian BanRDRan DingZLZhiQing Long

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Overview

Integrative analysis reveals carcinogenic effects of 1,4-phenylenediamine in hepatocellular carcinoma, suggesting potential risk assessment strategies.

Key Points

  • The research aims to identify the molecular mechanisms through which 1,4-phenylenediamine contributes to hepatocellular carcinoma.
  • Utilized a network toxicology framework for molecular mechanism elucidation.
  • Integrated toxicogenomic databases, transcriptomic profiles, and protein-protein interaction networks.
  • Employed a multi-algorithm machine learning pipeline combining random forest, LASSO regression, and support vector machines to refine targets.
  • Constructed a prognostic model via multivariate Cox regression for predictive validation.
  • Identified key targets linked to 1,4-phenylenediamine exposure associated with oncogenic pathways.
  • Validated the predictive performance of the prognostic model in independent cohorts.
  • Demonstrated activation of PI3K/AKT-MAPK and JAK/STAT signaling pathways, suggesting malignant progression.

Cite This Study

Ban et al. (2026) studied this question.

synapsesocial.com/papers/69d1fca7a79560c99a0a2474https://doi.org/10.1158/1538-7445.am2026-4138
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