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April 5, 2026Cancer Research

Abstract 4834: Keratin 17 correlates with epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma

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Authors

SSShayan SarkarLCLyanne Delgado CokaSPScott Powers

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Overview

Reveals the correlation between keratin 17 and EMT in pancreatic ductal adenocarcinoma, suggesting a potential target for poor prognosis treatment.

Key Points

  • To investigate the relationship between keratin 17 and epithelial-to-mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC).
  • Performed integrative single-cell transcriptomic analyses on treatment-naïve PDAC datasets.
  • Conducted differential gene expression and pathway enrichment analyses using RStudio.
  • Validated findings through cyclic multiplex immunofluorescence imaging and immunohistochemistry on human PDAC samples.
  • K17-positive PDAC cells showed transcriptional enrichment in the EMT pathway.
  • Markers such as ANXA1, S100A4, and LAMC2 were identified as associated with K17 expression.
  • Multiplex imaging confirmed lower epithelial differentiation in K17-positive tumor regions.

Cite This Study

Sarkar et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd29a79560c99a0a309bhttps://doi.org/10.1158/1538-7445.am2026-4834
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