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April 5, 2026Cancer Research

In Vivo Metastatic Prostate Tumor Model Using Bioluminescence Imaging

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Authors

VFVincent FaugerouxNHNicolás HoffmannSBSarah Belderbos

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Overview

Develops a metastatic prostate cancer model in mice, highlighting its utility for testing new therapies.

Key Points

  • The study aims to create a preclinical model of metastatic prostate cancer to facilitate the evaluation of new treatments.
  • Developed liver and lung metastases in immunodeficient male mice using 22Rv1-Luc-mCherry cells.
  • Monitored mice for clinical condition and weight three times per week.
  • Assessed tumor progression weekly with bioluminescence imaging for five weeks.
  • Conducted ex vivo imaging to verify metastatic sites after euthanasia.
  • Bioluminescence increased at the injection site initially, then in liver and lungs over five weeks.
  • After intra-arterial inoculation, early bioluminescence was primarily in bone, later increasing in the liver.
  • Ex vivo imaging confirmed metastasis to various organs including the liver and limb bones.

Cite This Study

Faugeroux et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd29a79560c99a0a30e5https://doi.org/10.1158/1538-7445.am2026-7539
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 4182: Development and evaluation of orthotopically and subcutaneously implanted luciferase-labeled prostate cancer xenograft models for therapeutic assessment2024
  2. 2Abstract 2143: From local growth to distant metastasis: A versatile in vivo imaging platform for modeling cancer progression.2026
  3. 3Abstract 7910: Advanced preclinical cancer models and imaging protocols for translational treatment studies in orthotopic prostate, bladder, liver, pancreatic and brain cancer2026
  4. 4Abstract 2824: Establishing prostate cancer models for orthotopic and bone metastatic growth using the 22Rv1cell line2024 · 1 citations
  5. 5Abstract B021: Modeling Human Immune Competent Patient-Derived Metastatic Prostate Cancer in Vivo2026