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April 5, 2026Cancer Research

Abstract 6104: STK11 loss enhances stress-adaptive programs supporting shear resilience in circulating tumor cells from KRAS-driven lung adenocarcinoma

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Authors

ASAnna ShowalterPRPrincess RodriguezDSDavid J. Seward

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Overview

Reveals STK11 loss enhances shear tolerance in circulating tumor cells, suggesting new therapeutic targets in KRAS-driven lung adenocarcinoma.

Key Points

  • This research aims to understand how STK11 loss affects the resilience of circulating tumor cells under mechanical stress in lung adenocarcinoma.
  • Used embryonic zebrafish xenograft model with KRAS-mutant and STK11-null lung adenocarcinoma cells.
  • Conducted longitudinal imaging of circulating tumor cell behavior in physiological circulation.
  • Analyzed RNA sequencing data under glutamine deprivation to assess stress response pathways.
  • Developed an FSS-specific gene panel to identify shear-adaptive programs.
  • STK11-null cells showed a higher micrometastatic burden and increased extravasation compared to parental controls.
  • RNA-seq analysis revealed enrichment of oxidative stress and stimulus-response pathways.
  • Identified NRF2-mediated antioxidant responses as crucial for shear adaptation in tumor cells.

Cite This Study

Showalter et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd3da79560c99a0a3234https://doi.org/10.1158/1538-7445.am2026-6104
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