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April 5, 2026Cancer Research

Abstract 3093: SLC25A28 is a synthetic lethal target in nucleotide excision repair-deficient cancer

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Authors

NYN. YangVJVijai JosephLHLisa Hoeg

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Overview

Genome-wide screen identifies SLC25A28 as a synthetic lethal target in NER-deficient cancers, suggesting new treatment options.

Key Points

  • This research aims to identify novel synthetic lethal targets in nucleotide excision repair-deficient cancers.
  • Generated an ERCC4 knockout cell line to study NER deficiency.
  • Conducted genome-wide CRISPR screening in NER-deficient and wild-type cells.
  • Validated candidate interactions through colony formation assays.
  • Assessed mechanism using RNA sequencing.
  • Confirmed ERCC4 knockout and reduced NER activity in ERCC4-deficient cells.
  • Identified SLC25A28 as a leading synthetic lethal candidate with ERCC4.
  • Demonstrated synthetic lethality between SLC25A28 and other ERCC genes.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd9ca79560c99a0a3b45https://doi.org/10.1158/1538-7445.am2026-3093
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