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April 5, 2026Cancer Research

Abstract 7151: Targeted inhibition of atypical PKC isoforms PKC-ι and PKC-ζ by ICA-1S and ζ-Stat suppresses oncogenic signaling and cytokine-mediated bone metastasis in prostate cancer

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Authors

GTGrazielly Caroline TeodoroWRWishrawana S. RatnayakeLLLuke Lajmi

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Overview

Investigates dual inhibition of PKC-ι and PKC-ζ to reduce bone metastasis in prostate cancer, suggesting a new therapeutic strategy.

Key Points

  • To explore the effects of ICA-1S and ζ-Stat on oncogenic signaling in prostate cancer cells and their bone microenvironment.
  • Used selective small-molecule inhibitors ICA-1S and ζ-Stat on DU-145 and PC-3 prostate cancer cell lines.
  • Analyzed cytokine levels to assess pro-metastatic and pro-inflammatory changes.
  • Performed immunofluorescence and co-immunoprecipitation assays to study protein interactions and localization.
  • ICA-1S and ζ-Stat reduced the activity and phosphorylation of PKC-ι/ζ and downstream signaling proteins.
  • Cytokine analysis showed significant downregulation of IL-6, IL-8, CXCL-1, and upregulation of IL-18 and ICAM-1.
  • Immunofluorescence revealed decreased nuclear localization of Stat3, suggesting reduced oncogenic signaling.

Cite This Study

Teodoro et al. (2026) studied this question.

synapsesocial.com/papers/69d1fd9ca79560c99a0a3b91https://doi.org/10.1158/1538-7445.am2026-7151
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