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April 5, 2026Cancer Research

Gene Polymorphisms in LEPR and PTGS2 for Prognostic Evaluation in Breast Cancer

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Authors

ASAlessandra Brandão de SouzaDFDaniely Regina Freitas-AlvesTSTaiana Sousa Lopes da Silva

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Overview

Investigative cohort study evaluates genetic impacts on breast cancer outcomes, suggesting tailored prognostic models.

Key Points

  • To assess the influence of LEPR and PTGS2 genetic variations on the prognosis of breast cancer outcomes.
  • Conducted a prospective cohort study with 1038 Brazilian women with nonmetastatic breast cancer over 10 years.
  • Genotyped blood samples for 14 SNPs from five genes using Real-Time PCR.
  • Evaluated survival using Kaplan–Meier method and hazard ratios through Cox regression multivariate models.
  • Assessed linkage disequilibrium and haplotypes using Haploview.
  • LEPR rs1137101 was linked to improved disease-free survival (DFS) across various patient subgroups.
  • PTGS2 rs689466 was associated with worse DFS and breast cancer-specific survival (BCSS), particularly in post-menopausal and obese patients.
  • Combination of LEPR and PTGS2 polymorphisms provided insights into patient prognosis, indicating the relevance of personalized prognostic models.

Cite This Study

Souza et al. (2026) studied this question.

synapsesocial.com/papers/69d1fdd4a79560c99a0a4276https://doi.org/10.1158/1538-7445.am2026-2306
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