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April 5, 2026Cancer Research

Abstract 916: Prevalence of screen-detectable cancers among adults aged 18-49 years: Findings from HINTS-SEER.

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Why the study?

Population-level estimates of the burden of screen-detectable cancers among younger adults remain poorly characterized, limiting efforts to inform public health strategies.

Population

298 cancer survivors aged 18-49 years (weighted N ≈ 119,131)

Design

Registry-linked national survey

Key result

Screen-detectable cancers accounted for 60.0% of cancer diagnoses among adults aged 18-49, driven primarily by breast (29.0%) and non-melanoma skin (16.1%) cancers.

Authors

GKGaurav Y. KulkarniMUMatthew UntalanWLWayne R. Lawrence

Discussion

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Overview

Supports refining screening in adults 18-49; extends observational data but leaves open optimal approaches.

Key Points

  • This study aims to quantify the prevalence and distribution of screen-detectable cancers among adults diagnosed before age 50.
  • Utilized data from the 2022 HINTS-SEER survey
  • Calculated weighted prevalence estimates for cancer survivors aged 18-49
  • Categorized cancers by site: breast, colorectal, cervical, lung, prostate, and non-melanoma skin
  • Stratified findings by birth sex, race, and ethnicity
  • Screen-detectable cancers accounted for 60.0% of diagnoses
  • Breast cancer prevalence was 29.0%, non-melanoma skin 16.1%, colorectal 7.2%, prostate 4.3%, lung 2.3%, cervical 1.0%
  • Mean age of diagnosis varied by site, with cervical cancer at 28.2 years and colorectal at 43.0 years
  • Sample was predominantly female (67.6%) and ethnically diverse, with 73.6% non-Hispanic White

Structured PICO

P
Population
298 respondents (weighted N ≈ 119,131) aged 18-49 years who are cancer survivors from the HINTS-SEER registry.
O
Outcome
Prevalence and distribution of screen-detectable cancers

Screen-detectable cancers represent a substantial proportion (60%) of early-onset cancers in adults aged 18-49, highlighting opportunities for refining screening strategies.

Limitations

  • Subgroup estimates were limited by small sample sizes

Cite This Study

Kulkarni et al. (2026) studied this question. Screen-detectable cancers accounted for 60.0% of cancer diagnoses among adults aged 18-49, driven primarily by breast (29.0%) and non-melanoma skin (16.1%) cancers.

synapsesocial.com/papers/69d1fde4a79560c99a0a43d3https://doi.org/10.1158/1538-7445.am2026-916
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 768: Awareness and use of genetic testing among cancer survivors in the United States: A HINTS-SEER study2024
  2. 2Abstract LB395: Potential survival benefits from early detection: Development and results of a multi-cancer simulation model2026
  3. 3Abstract A074: An epidemiological analysis of racial and geographic disparities in self-reported solid tumor prevalence: Insights from HINTS 5, cycle 1 on US cancer burden2025
  4. 4Abstract 6075: Most cancer deaths are unaddressed by current screening paradigms2024
  5. 5Temporal changes in age at diagnosis and the proportion of early-onset cases among diagnosed cases of 16 selected cancers in the United States, 2000–20232026