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April 5, 2026Cancer Research0 citations

Association of Tumor Infiltrating Lymphocytes and Proinflammatory Biomarkers with Breast Cancer...

Abstract 6263: Association of tumor infiltrating lymphocytes and proinflammatory biomarkers with breast cancer molecular subtypes: Analysis of the MEND study.

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Authors

JBJovita ByemerwaDNDrew NeishADApril Deveaux

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Overview

Analysis of tumor infiltrating lymphocytes and proinflammatory biomarkers reveals associations with breast cancer subtypes in Nigerian women, suggesting implications for immunotherapy.

Key Points

  • This study aims to evaluate the association of tumor infiltrating lymphocytes and proinflammatory biomarkers with breast cancer molecular subtypes in Nigerian women.
  • Analyzed 436 newly diagnosed, treatment-naïve breast cancer patients from Nigeria.
  • Characterized breast cancer molecular subtypes using immunohistochemistry.
  • Quantified tumor infiltrating lymphocytes on H&E-stained slides as per International TILs Working Group criteria.
  • Assessed serum levels of proinflammatory biomarkers (e.g., IL-6, TNF-α) using immunoassays.
  • Utilized multivariable logistic and multinomial regression to determine associations.
  • 43% of tumors were TNBC subtype; 52.8% were grade 2 or 3 tumors.
  • Median TIL percentage was 10.0%, with 49% categorized as low.
  • High TIL levels were associated with approximately 5-fold higher odds of being diagnosed with TNBC.
  • Increased TNF-α levels correlated significantly with higher odds of TNBC after adjustments.
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Byemerwa et al. (2026) studied this question.

synapsesocial.com/papers/69d1fde4a79560c99a0a440bhttps://doi.org/10.1158/1538-7445.am2026-6263
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