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April 5, 2026Cancer Research

Characterization of Doxycycline Inducible EZH2 Overexpression Model in Mammary Glands

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Authors

AEAhmad EidoMGMaria E. GonzalezLSL. Syu

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Overview

Demonstrates EZH2 overexpression induces hyperbranching in mammary glands, suggesting potential implications for breast cancer.

Key Points

  • To establish a new model for studying EZH2 overexpression in mammary glands and its potential role in breast cancer.
  • Developed a doxycycline-inducible transgenic mouse model for EZH2 overexpression in mammary epithelial cells.
  • Administered doxycycline to 10-week-old female mice to induce EZH2 overexpression.
  • Analyzed mammary glands using whole-mount staining, histopathology, and immunostaining for EZH2.
  • Induction of EZH2 expression increased ductal branch counts compared to control groups.
  • Long-term EZH2 induction led to a hyperbranching phenotype and mammary epithelial nodules.
  • Findings suggest that EZH2 overexpression mimics features of human preneoplastic lesions.

Cite This Study

Eido et al. (2026) studied this question.

synapsesocial.com/papers/69d1fdf7a79560c99a0a4616https://doi.org/10.1158/1538-7445.am2026-6096
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 4831: Inducible models of EMT reveal dynamic changes in the tumor-immune microenvironment2026
  2. 2Abstract 533: Attenuating EZH2-mediated metastasis and tumor growth by pharmacological-based approaches using three-dimensional in vitro culture models2024
  3. 3Abstract 608: Ccn6 loss cooperates with EZH2 overexpression to induce sarcomatoid differentiation in metaplastic breast carcinoma.2026
  4. 4Abstract PO4-16-01: EZH2 is Overexpressed in Invasive Carcinoma and DCIS in both BRCA1 and BRCA2 Mutation Carriers2024
  5. 5Abstract PO1-24-05: EZH2 histone methyltransferase activity promotes spindle metaplastic breast carcinoma metastasis and is induced by CCN6 knockout/b-catenin/TCF axis2024