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April 5, 2026Journal of Lower Genital Tract Disease1 citations

Pain Control for Outpatient Colposcopy, Loop Electrode Excision Procedure, Vulvar Biopsy, and Endometrial Biopsy

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MHMary HillardAEAllison K. EtcheverryGSG Smotrich

Key Points

  • To evaluate the effectiveness of various pain control options during outpatient gynecological procedures.
  • Review of pain control techniques for EMB, vulvar biopsy, colposcopy, and LEEP.
  • Comparison of lidocaine spray, IUL, PCB, and oral NSAIDs for pain relief.
  • Assessment of VAS scores for pain during procedures.
  • Lidocaine spray, IUL, PCB, and oral NSAIDs were effective for EMB pain control.
  • VAS scores indicate significant changes during vulvar biopsy compared to baseline.
  • Lidocaine injection proved superior to nonpharmacologic methods like music for colposcopy and LEEP.

Abstract

Lidocaine spray, IUL, PCB, and oral NSAIDs were found to be effective pain control options during EMB. Vulvar biopsy is largely unstudied, but the procedure induces significant changes in VAS scores as compared with patient baselines. For colposcopy and LEEP, local anesthetic with injection of lidocaine is superior to nonpharmacologic interventions such as music. Lidocaine spray remains a better alternative than no pain intervention. Patient preference, while variable, is an important factor to consider when choosing an anesthetic intervention.

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Cite This Study

Hillard et al. (2026) studied this question.

synapsesocial.com/papers/69d1fe07a79560c99a0a47d7https://doi.org/10.1097/lgt.0000000000000945
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy of Lidocaine Spray for Pain Reduction during Colposcopy-Directed Cervical Biopsies: A Randomized Controlled Trial2024 · 4 citations
  2. 2Can Rectal Indomethacin Be an Alternative Local Anesthetic Method to Intrauterine Lidocaine During Endometrial Biopsy? A Clinical Observational Prospective Study2020 · 1 citations
  3. 3Sensation of Pain Using Buffered Lidocaine for Infiltration Before Vulvar Biopsy2020 · 5 citations
  4. 4Pain Sensation During Colposcopy and Cervical Biopsy, With or Without Local Anesthesia: A Randomized Trial2017 · 19 citations
  5. 5Summarizing systematic reviews2015 · 2,651 citations