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April 5, 2026Cancer Research

Abstract 7371: High-definition spatial and single-cell multiomics reveal immunological remodeling and radiation resistance mechanisms in colorectal cancer

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Authors

JKJunbum KimOEOlivier ElementoCMChristina Montagna

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Overview

Analysis reveals immunological remodeling and systemic immune shifts during radiation therapy in colorectal cancer.

Key Points

  • This research aims to uncover mechanisms of radiation resistance in colorectal cancer by studying immune changes and tissue remodeling.
  • Integrated high-definition spatial and single-cell profiling
  • Patient sampling before treatment, after radiation, and at surgery
  • Use of VisiumHD technology for detailed spatial mapping
  • Single cell RNA sequencing on matched blood samples
  • Identification of an activation of macrophages at the tumor stroma boundary
  • Evidence of a macrophage-dependent repair niche facilitating tumor persistence
  • Observation of early immune activation followed by a shift to immune suppression
  • Findings show disruptions in lymph node structure and reduced cytotoxic T cell populations

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/69d1fe07a79560c99a0a4887https://doi.org/10.1158/1538-7445.am2026-7371
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