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April 5, 2026Medicine & Science in Sports & Exercise0 citations

Acute Aerobic Walking Exercise Induces Changes in Thalamic Resting-State Connectivity in Persons with Multiple Sclerosis

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BSBrian M. SandroffRMRobert W. MotlHNHaley Nauman

Key Points

  • To investigate how acute aerobic walking exercise affects thalamic resting-state connectivity in individuals with multiple sclerosis.
  • Performed single bouts of aerobic walking exercise
  • Assessed thalamic resting-state functional connectivity (RSFC)
  • Compared effects based on multisensory input from overground walking (OG) versus treadmill (TM) walking.
  • Observed significant changes in thalamic RSFC linked to cognitive functions
  • Changes varied between overground and treadmill walking conditions
  • Suggests aerobic walking may enhance cognitive processes in MS.

Abstract

This study provides the first empirical evidence that single bouts of aerobic walking exercise induce changes in thalamic RSFC across several regions that are important for cognition in MS, and this differed based on multisensory input associated with OG versus TM. Such evidence provides important insight into potential mechanisms for why aerobic walking exercise might improve cognition in persons with MS.

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Cite This Study

Sandroff et al. (2026) studied this question.

synapsesocial.com/papers/69d1fe68a79560c99a0a4af2https://doi.org/10.1249/mss.0000000000003998
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Feasibility of Aerobic Exercise in People With Advanced Multiple Sclerosis: Characterizing Acute Responses to Inform Exercise Prescription2025 · 1 citations
  2. 2Brain neuroplasticity in multiple sclerosis patients in functional magnetic resonance imaging studies. Part 2: Effect of aerobic training2024
  3. 3The Effect of Dual-Task Training and Rhythmic Aerobics on Cognitive Function in Women With MS2025
  4. 4Does Aerobic Exercise Influence Intrinsic Brain Activity? An Aerobic Exercise Intervention among Healthy Old Adults2017 · 72 citations
  5. 5Effects of a 12-Week Aerobic Spin Intervention on Resting State Networks in Previously Sedentary Older Adults2018 · 47 citations