Does lovastatin reduce the risk for the first acute major coronary event in men and women with average TC and LDL-C levels and below-average HDL-C levels?
Men and women with average TC and LDL-C levels and below-average HDL-C levels
Lovastatin
First acute major coronary eventhard clinical
Lovastatin reduces the risk of first acute major coronary events in patients with average LDL-C but below-average HDL-C, suggesting a need to reassess guidelines.
Lovastatin reduces the risk for the first acute major coronary event in men and women with average TC and LDL-C levels and below-average HDL-C levels. These findings support the inclusion of HDL-C in risk-factor assessment, confirm the benefit of LDL-C reduction to a target goal, and suggest the need for reassessment of the National Cholesterol Education Program guidelines regarding pharmacological intervention.
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John R. Downs
Michael Clearfield
Stephen E. Weis
JAMA
Cornell University
University of North Texas
Merck (Japan)
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Downs et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69d32fbdef7f7168a702f6ce — DOI: https://doi.org/10.1001/jama.279.20.1615