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April 7, 2026Digestive and Liver Disease0 citationsOpen Access

Dietary and nutraceutical interventions for functional dyspepsia: A narrative review

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APAndrea PastaEFElena FormisanoFCFrancesco Calabrese

Key Points

  • The aim is to evaluate dietary and nutraceutical interventions for managing functional dyspepsia and their mechanisms.
  • Narrative review of existing meta-analyses, randomized trials, and observational studies.
  • Assessment of dietary modifications including meal frequency and texture adjustments.
  • Review of specific nutraceutical agents and their effects on FD symptoms.
  • Small, regular, lower-fat meals help reduce FD symptoms.
  • Low-FODMAP diets show effectiveness in select patients, especially those with bloating.
  • Nutraceuticals like peppermint–caraway and ginger demonstrate symptomatic relief.

Abstract

Abstract Functional dyspepsia (FD) is a prevalent disorder of gut–brain interaction. Commonly, meals may exacerbate FD symptoms like postprandial fullness, early satiation, epigastric pain, and nausea. We narratively synthesize meta-analyses, randomized trials, and observational evidence to outline mechanism-based dietary and nutraceutical options. Evidence favors small, regular, lower-fat meals and adjusting texture/osmolarity to minimize gastric distension. In selected phenotypes—particularly postprandial distress with bloating—a brief, dietitian-supervised low-FODMAP trial with staged reintroduction can define personal thresholds. Among nutraceuticals, peppermint–caraway, ginger, STW-5, curcumin, and selected probiotics show benefit, with melatonin and barrier-forming agents promising in subsets, while safety remains product-specific.

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Cite This Study

Pasta et al. (2026) studied this question.

synapsesocial.com/papers/69d49f44b33cc4c35a227b10https://doi.org/10.1016/j.dld.2026.03.010
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