What does this research mean for the field?

Very high output pace-capture testing (20 mA at 10 ms) for posterior wall isolation in persistent atrial fibrillation does not improve arrhythmia-free survival and is paradoxically associated with higher recurrence rates compared to standard testing. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

To assess the impact of very high output pace-capture testing on atrial fibrillation recurrence after posterior wall isolation.

April 7, 2026

Utility of Very High Output Pace‐Capture Testing for Posterior Wall Isolation in Patients With Persistent Atrial Fibrillation

Puntos clave

To assess the impact of very high output pace-capture testing on atrial fibrillation recurrence after posterior wall isolation.
Retrospective study of patients who underwent radiofrequency ablation for persistent atrial fibrillation.

PICO estructurado

Does very high output pace-capture testing (20 mA at 10 ms) for posterior wall isolation reduce AF/AT recurrence in patients with persistent atrial fibrillation compared to standard testing (10 mA at 2 ms)?

Población

232 patients with persistent atrial fibrillation undergoing radiofrequency ablation including pulmonary vein isolation (PVI), posterior wall isolation (PWI), and a cavotricuspid isthmus (CTI) line.

Intervención

Very high output pace-capture testing on the posterior wall using 20 mA at 10 ms (20 × 10), with additional lesions performed if captured.

Comparador

Standard output pace-capture testing on the posterior wall using 10 mA at 2 ms (10 × 2), with additional lesions performed if captured.

Resultado

Recurrent atrial fibrillation or atrial tachycardia (AF/AT)hard clinical

Very high output pace-capture testing (20 mA at 10 ms) to confirm posterior wall isolation in persistent AF paradoxically increased arrhythmia recurrence compared to standard testing, questioning the overall efficacy of PWI.

Resumen

ABSTRACT Background Pulmonary vein isolation (PVI) and posterior wall isolation (PWI) are frequently used in the treatment of persistent atrial fibrillation (AF). Minimal data support adjunct PWI, possibly due to lack of durability via epicardial reconnections. Objective To determine the impact of very high output PW pace‐capture testing in patients with persistent AF on AF/AT recurrence. Methods We performed a retrospective study of consecutive patients who underwent radiofrequency ablation for persistent AF and received PVI and PWI, as well as a cavotricuspid isthmus line (CTI). After the creation of three linear PW lesions (roof, carina‐to‐carina, and inferior PV levels), pace‐capture testing was performed on the PW. The first cohort confirmed PWI using 10 mA at 2 ms (10 × 2) to pace capture. Sequentially, the second cohort utilized 20 mA at 10 ms (20 × 10). If the PW was captured, additional lesions were performed. Patients were excluded if additional lesion sets beyond PVI, PWI, and CTI were performed. Results A total of 232 patients were included. Of these, 129 (56%) patients were in the 20 × 10 group, and 103 (44%) patients were in the 10 × 2 group. The two groups did not differ in age, sex, proportion of comorbidities, presenting rhythm, left ventricular ejection fraction, or left atrial size. Despite the increase in procedure time and lesion number, in the time‐to‐event analysis, patients in the 20 × 10 group experienced recurrent AF/AT more frequently than those in the 10 × 2 group (log rank p = 0.01). Conclusion Testing PWI in persistent AF with pace capture at 20 mA at 10 ms did not improve freedom from arrhythmia and may paradoxically be associated with harm. Our findings question whether PWI, regardless of durability, is effective in treating persistent AF.

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