Does male sex worsen prognosis regarding major cardiac events and mortality in LMNA mutation carriers?
Male LMNA mutation carriers face a worse prognosis than females, driven by higher rates of malignant ventricular arrhythmias and end-stage heart failure.
This large cohort of LMNA mutation carriers demonstrates a high cardiac disease penetrance and a high mortality in mutation carriers. Male mutation carriers have a worse prognosis due to a higher prevalence of malignant ventricular arrhythmias and end-stage heart failure.
Rijsingen et al. (2012) studied this question.