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October 1, 2021EuroIntervention24 citationsOpen Access

Incidence and clinical impact of major bleeding following left atrial appendage occlusion: insights from the Amplatzer Amulet Observational Post-Market Study

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AAAdel AminianOBOle De BackerJNJens Erik Nielsen‐Kudsk

Key Points

  • To evaluate the incidence and clinical impact of major bleeding following left atrial appendage occlusion in high-risk patients.
  • Observed real-world patients undergoing left atrial appendage occlusion (LAAO) for high bleeding risk
  • Analyzed clinical outcomes, including mortality and stroke
  • Used ClinicalTrials.gov Identifier: NCT02447081 for reference.
  • Major bleeding occurred frequently in this high-risk population
  • Significant increase in mortality associated with major bleeding was noted
  • No increase in stroke risk was observed following major bleeding incidents.

Abstract

In real-world patients at high bleeding risk, MB following LAAO was not uncommon and associated with a significant increase in mortality, without increasing the risk of stroke. ClinicalTrials.gov Identifier: NCT02447081. https://clinicaltrials.gov/ct2/show/NCT02447081.

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Cite This Study

Aminian et al. (2021) studied this question.

synapsesocial.com/papers/69d5724975589c71d767e6d2https://doi.org/10.4244/eij-d-20-01309
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