Impact of immunochemotherapy administration sequence on overall survival in advanced esophageal and gastric cancers: a propensity score-matched multicenter analysis

Key Points

• The aim is to evaluate how the sequence of chemotherapy and immunotherapy affects overall survival in advanced esophageal and gastric cancers.
• Propensity score-matched multicenter analysis conducted on patients with advanced esophageal and gastric cancers.
• Assessment of overall survival based on the timing of chemotherapy relative to immunotherapy.
• Comparison of outcomes between those receiving chemotherapy first versus those receiving immunotherapy first.
• Administering chemotherapy prior to immunotherapy significantly improves overall survival.
• Improvement in survival is particularly evident when chemotherapy is used as first-line treatment.
• Findings suggest the importance of treatment sequencing in enhancing patient outcomes.