Experimental Evaluation of Ovulation Inducing Activity of Mahachaitasa Ghrita in Female Wister Albino Rats

Infertility affects approximately 17.5% of the global adult population and nearly 15% in India, exerting substantial psychosocial burden on affected women. In Ayurveda, Rutu, Kshetra, Ambu, and Beeja constitute the fundamental prerequisites for conception, and their vitiation results in Vandhyatva, with anovulation being a predominant etiological factor. Mahachaitasa Ghrita, a classical Sneha Kalpana formulation indicated for Manovaha Srotovikara and Vandhyatva as described in Bhavaprakasha, was evaluated for its ovulation-inducing potential in female Wistar albino rats. Animals were randomized into four groups (n = 6). Experimental findings revealed a statistically significant prolongation of the estrous phase, elevation of serum estrogen levels, and increased endometrial thickness, reflecting estrogenic stimulation characteristic of the proliferative phase.