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April 8, 2026CureusOpen Access

Biologically Driven Tooth Regeneration: A Scoping Review of Stem Cell-Based Approaches

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Authors

NSNiti SinghDJDaniel E. E Moore JrAKAdarsh Keshari

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Overview

Scoping review synthesizes stem cell and scaffold combinations for effective tooth regeneration, suggesting new treatment pathways.

Key Points

  • The review aims to explore the potential of various stem cell sources and regenerative materials in tooth regeneration.
  • Conducted a scoping review following PRISMA-ScR guidelines.
  • Reviewed preclinical and early clinical studies on stem cells and scaffolds.
  • Analyzed the effectiveness of various combinations of stem cells, scaffolds, and signaling factors.
  • DPSCs and SHED are the most investigated stem cell sources for regeneration.
  • Combination of scaffolds and factors like VEGF and FGF led to successful tissue formation and mineralization.
  • Significant variability among studies was noted due to differences in methodologies and materials used.

Cite This Study

Singh et al. (2026) studied this question.

synapsesocial.com/papers/69d5f10974eaea4b11a7a90dhttps://doi.org/10.7759/cureus.106495
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stem cell-driven biomedical technologies for tooth regeneration: engineering scaffolds, organoid models, and molecular targeted strategies.2026
  2. 2Tooth Tissue Engineering: Recent Advances, Key Techniques, and Translational Challenges2025
  3. 3Biological tooth repair: Harnessing dental stem cells for regenerative therapy and functional restoration of dental tissues2026
  4. 4Regenerative Dentistry and Dental Tissue Engineering: Contemporary Strategies, Biomaterials, and Clinical Applications2026
  5. 5Stem Cell Innovations in Dentistry: Advancing Neuroregeneration, Periodontal Repair, and Craniofacial Reconstruction2025