Does GLP-1 RA treatment improve mitochondrial function, inflammatory markers, and leukocyte-endothelium interactions in patients with type 2 diabetes?
Patients with type 2 diabetes (T2D)
GLP-1 receptor agonists (GLP-1 RA)
Redox state, mitochondrial respiration, leukocyte-endothelial interactions, inflammation, and carotid intima-media thickness (CIMT)surrogate
GLP-1 receptor agonists improve mitochondrial function and reduce inflammatory and vascular surrogate markers in type 2 diabetes, suggesting a mechanism for cardiovascular risk reduction.
GLP-1 RA treatment improves the redox state and mitochondrial respiration, and reduces leukocyte-endothelial interactions, inflammation and CIMT in T2D patients, thereby potentially diminishing the risk of atherosclerosis and CVDs.
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Clara Luna-Marco
Arantxa Martinez de Marañon
Alberto Hermo-Argibay
Redox Biology
SHILAP Revista de lepidopterología
Universitat de València
University College Cork
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
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Luna-Marco et al. (Mon,) studied this question.
www.synapsesocial.com/papers/69d7edefa2a48916bbbee609 — DOI: https://doi.org/10.1016/j.redox.2023.102849
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