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Spatial and molecular characteristics determine tissue function, yet high-resolution methods to capture both concurrently are lacking. Here, we developed high-definition spatial transcriptomics, which captures RNA from histological tissue sections on a dense, spatially barcoded bead array. Each experiment recovers several hundred thousand transcript-coupled spatial barcodes at 2-μm resolution, as demonstrated in mouse brain and primary breast cancer. This opens the way to high-resolution spatial analysis of cells and tissues.
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Vicković et al. (Mon,) studied this question.
www.synapsesocial.com/papers/69d8124b5c3030ff03d1908b — DOI: https://doi.org/10.1038/s41592-019-0548-y
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:
Sanja Vicković
Gökçen Eraslan
Fredrik Salmén
Nature Methods
Harvard University
Stanford University
Massachusetts Institute of Technology
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