An up-to-date review on water-soluble tomato concentrate (Fruitflow®) and healthy ageing: roles of its bioactive compounds and mechanism of action

Ageing is a complex biological process marked by gradual functional decline, reduced cellular resilience, and increased vulnerability to chronic diseases. Maintaining cell health has become a crucial strategy for extending life span and promoting healthy ageing. Nutrition at the cellular level plays a vital role in the increasing recognition of bioactive compounds from functional foods for their ability to influence pathways related to ageing. The water-soluble tomato concentrate (WSTC), known as Fruitflow® , contains a variety of bioactive compounds, including polyphenols, nucleosides, and phenolic conjugates, that support cardiovascular, metabolic, and immune health. Preclinical and clinical research suggest that Fruitflow® may help reduce platelet hyperactivity, support healthy blood pressure, and improve blood vessel function. Emerging evidence also indicates that it could have broader cellular effects, such as helping reduce oxidative stress and inflammation, supporting mitochondrial activity, promoting cellular growth, and contributing to a balanced gut microbiota. These potential benefits are relevant to several aspects of cellular ageing, including oxidative imbalance, mitochondrial dysfunction, chronic inflammation, and changes in cellular communication. Over the last two decades, various authors have published their research work on the potential health benefits of WSTC/Fruitflow®. This review summarises current evidence on the cellular effects of bioactive compounds present in Fruitflow® and explores the potential molecular mechanisms through which these bioactive constituents may influence cellular processes associated with health benefits. • Fruitflow®/WSTC bioactive compounds support mitochondria, DNA integrity, and stress defense. • It may act on hallmarks of ageing: methylation, telomeres, senescence, and NAD + balance. • Beyond cardioprotection, Fruitflow® may aid resilience and healthy ageing.