What question did this study set out to answer?

This research examines how changes in oral anticoagulant usage influence the incidence of intracerebral hemorrhage.

April 10, 2026Open Access

Changes in the use of vitamin K antagonists and direct oral anticoagulants and impact on the incidence of oral anticoagulation-related intracerebral hemorrhage: population-wide prescription patterns in two 5-year cohorts

Key Points

This research examines how changes in oral anticoagulant usage influence the incidence of intracerebral hemorrhage.
Analyzed population-wide prescription patterns

Structured PICO

Do direct oral anticoagulants reduce the incidence of oral anticoagulation-related intracerebral hemorrhage compared to vitamin K antagonists?

Population

Population-wide cohorts of patients receiving oral anticoagulants over two 5-year periods

Intervention

Direct oral anticoagulants (DOACs)

Comparator

Vitamin K antagonists (VKAs)

Outcome

Incidence of oral anticoagulation-related intracerebral hemorrhage (ICH)safety

Population-wide data demonstrates that despite a near-doubling of oral anticoagulant use, intracerebral hemorrhage incidence remained stable, driven by the safety advantage of DOACs over VKAs.

Abstract

ICH incidence remained stable despite near-doubled OAC use. The lower ICH rates with DOACs compared to VKAs support their safety advantage.

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Discussion

Authors

Liisa Tomppo

Hanne Sallinen

Otto Lankinen

Journals

SHILAP Revista de lepidopterología

Annals of Medicine

Actions

Institutions

King's College London

University of Helsinki

Helsinki University Hospital

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Changes in the use of vitamin K antagonists and direct oral anticoagulants and impact on the incidence of oral anticoagulation-related intracerebral hemorrhage: population-wide prescription patterns in two 5-year cohorts

Key Points

Structured PICO

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study