What question did this study set out to answer?

This research aims to identify and understand the molecular pathways involved in human skin aging using single-cell transcriptomics.

April 10, 2026Open Access

Single‐Cell Transcriptomics Reveal Human Skin Aging Pathways

Key Points

This research aims to identify and understand the molecular pathways involved in human skin aging using single-cell transcriptomics.
Utilized single-cell transcriptomics to analyze gene expression in human skin samples.
Identified differentially expressed genes (DEGs) across various skin conditions.
Employed pathway enrichment analysis to explore biological processes affected by aging.
Identified key pathways associated with skin aging such as HNF and HNK.
Demonstrated alterations in gene expression related to skin health as individuals age.
Revealed specific differentially expressed genes that may serve as therapeutic targets.

Abstract

The data that support the findings of this study are available from the corresponding author upon reasonable request. FIGURE S1: (A) Venn view of DEGs from FB (blue), KTd (yellow) and Ktu (purple). (B) Enriched Wikipathways in FB (HNF) and KT (HNK). “Count” indicate gene number modulated in each pathway. TABLE S1: Description of the skin samples enrolled in this study. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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Cite this study

Melyukhina et al. (Wed,) studied this question.

www.synapsesocial.com/papers/69d8930e6c1944d70ce04352 — DOI: https://doi.org/10.1111/jocd.70708

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Authors

Kseniya Melyukhina

Anne‐Laure Bulteau

Carine Nizard

Journals

Journal of Cosmetic Dermatology

Actions

Institutions

Brigham and Women's Hospital

LVMH (France)

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Single‐Cell Transcriptomics Reveal Human Skin Aging Pathways

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion