What question did this study set out to answer?

This research aims to investigate the role of miR-301b-3p in breast cancer and its impact on cisplatin sensitivity.

April 10, 2026

Mir‐301b‐3p Targets Alx4 to Suppress Cisplatin Sensitivity in Breast Cancer through DNA Damage

Key Points

This research aims to investigate the role of miR-301b-3p in breast cancer and its impact on cisplatin sensitivity.
Examined the effects of miR-301b-3p on breast cancer cell proliferation and cisplatin sensitivity
Investigated the regulatory relationship between miR-301b-3p and ALX4
Analyzed the involvement of DNA damage pathways in the mechanism of action.
miR-301b-3p promotes breast cancer cell proliferation
miR-301b-3p reduces sensitivity to cisplatin
ALX4 suppression is linked to the observed changes in DNA damage response.

Abstract

This study demonstrates that miR-301b-3p promotes BC proliferation and reduces cisplatin sensitivity by suppressing ALX4, a mechanism mediated through the regulation of DNA damage pathways. These findings offer new insights into cisplatin resistance and suggest potential therapeutic targets for overcoming chemoresistance in BC.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Cite this study

Yan et al. (Wed,) studied this question.

www.synapsesocial.com/papers/69d893406c1944d70ce04561 — DOI: https://doi.org/10.1002/adbi.202500715

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

MiR-301b-3p Promotes the Occurrence and Development of Breast Cancer Cells via Targeting HOXA5· 2021 · 13 citations
Cisplatin in cancer treatment· 2022 · 333 citations
Platinum-based systematic therapy in triple-negative breast cancer· 2022 · 83 citations
MicroRNA-Based Biomarkers in Lung Cancer: Recent Advancesand Potential Applications· 2022 · 14 citations
Breast Cancer Treatment· 2019 · 4,802 citations

Authors

Yushan Yan

Jiliang Xia

Tingting Ma

Journals

Advanced Biology

Actions

Institutions

Xuzhou Medical College

Second People’s Hospital of Huai’an

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Mir‐301b‐3p Targets Alx4 to Suppress Cisplatin Sensitivity in Breast Cancer through DNA Damage

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion