Mechanism of Gzma‐mediated GEF‐H1 activation in intestinal epithelial cells leading to intestinal barrier dysfunction in sepsis

Key Points

• The study investigates how Gzma activates GEF-H1 to cause intestinal barrier dysfunction during sepsis.
• In vivo experiments using septic mice
• Knockout of GEF-H1
• Treatment with Epothilone A
• Analysis of survival rates and organ protection
• Gzma dephosphorylates Ser886 on GEF-H1, activating the RhoA/ROCK pathway
• Knockout of GEF-H1 reduces intestinal damage and increases survival in septic mice
• Epothilone A restores intestinal barrier function and lowers mortality in sepsis

Abstract