Expression of Notch signaling pathway in children with Henoch-Schönlein purpura and its correlation with inflam-matory cytokines

Key Points

• This research aims to investigate the role of the Notch signaling pathway in children with Henoch-Schönlein purpura and its relationship with inflammatory cytokines.
• Measured mRNA expression levels of NOTCH1 and NOTCH2 during the acute phase of HSP.
• Investigated the correlation between Notch signaling activation and pro-inflammatory cytokine levels.
• Analyzed the association of Notch expression with disease severity.
• Notch signaling was significantly activated in the acute phase of Henoch-Schönlein purpura.
• There is a potential correlation between NOTCH1 and NOTCH2 expression levels and the severity of the disease.
• The findings suggest that these markers could be useful for assessing disease progression.

Abstract