Efficacy and Safety of Extended-Release Clonidine Hydrochloride for Attention Deficit Hyperactivity Disorder in Chinese Children and Adolescents: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

Key Points

• To assess the efficacy and safety of extended-release clonidine hydrochloride in treating ADHD in Chinese children and adolescents.
• Randomized, double-blind, placebo-controlled trial design
• Involved multiple centers in China
• Participants included children and adolescents diagnosed with ADHD
• Compared results of clonidine versus placebo
• Clonidine hydrochloride showed significant efficacy in reducing ADHD symptoms
• The treatment was well tolerated with minimal side effects
• Findings support its viability as a nonstimulant option for ADHD management

Abstract