Programmable Dual‐Targeting Nano Bioconjugates: a Universal Bioconjugation Strategy to Enhance Single Molecule Proteomic Assays (Small Methods 7/2026)

Front Cover The image illustrates programmable dual-targeting nano-bioconjugates formed by assembling bispecific antibody fragments (BsAbs) on PEGylated nanoparticle clusters. BsAbs enable precise dual recognition at the single-molecule level, demonstrating the specificity and modularity of this strategy. Controlled BsAb-F conjugation on mPEG nanoparticles improves SERS-based biosensing for ultrasensitive, multiplexed biomarker detection and supports broader applications in functional nanomaterial design. More in article number e01235, Alain Wuethrich, Christopher B. Howard, Matt Trau, and co-workers.