SREBF2 drives osteoporosis by divergently regulating Hippo/YAP-mediated adipogenesis and BMP/Smad-mediated osteogenesis in bone marrow stromal cells

Key Points

• The study aims to explore how SREBF2 influences the balance between fat cell formation and bone cell formation in bone marrow stromal cells.
• Examined the role of SREBF2 in bone marrow stromal cells (BMSCs)
• Analyzed the effects on Hippo/YAP and BMP/Smad pathways
• Investigated adipogenesis and osteogenesis processes
• SREBF2 activation increased adipocyte formation via Hippo/YAP pathway
• SREBF2 inhibited bone formation through the BMP/Smad pathway
• Targeting SREBF2 showed potential as a therapeutic approach for osteoporosis

Abstract