Tracking tau and cellular responses in human iPSC‐microglia: from uptake to seedable secretion, including in extracellular vesicles

Key Points

• The research aims to investigate how human microglia respond to tau and the mechanisms involved in its spread.
• Examined responses of human iPSC-derived microglia to tau
• Analyzed tau uptake and secretion in microglial cells
• Investigated the role of extracellular vesicles in tau propagation.
• New insights into tau uptake mechanisms by microglia
• Identification of seedable tau secretion pathways
• Opportunities highlighted for limiting pathogenic tau spread.

Abstract