Molecular Characterization of the Effect of Glucagon-Like Peptide-1 Receptor Agonist Semaglutide in the Nephrotoxic Serum Nephritis Mouse Model

Key Points

• This research aims to investigate the effects of semaglutide on nephrotoxic serum nephritis models related to chronic kidney disease.
• Utilized a nephrotoxic serum nephritis mouse model.
• Administered semaglutide treatment to the rodents.
• Assessed kidney function and related molecular pathways.
• Semaglutide exhibited beneficial effects on kidney function.
• These effects were independent of its roles in weight loss or blood sugar control.

Abstract