Comparative Analysis of Stromal Tumor Infiltrating Lymphocytes in Various Grades and Molecular Subtypes of Breast Carcinoma

Key Points

• To investigate the variation of stromal tumor infiltrating lymphocytes (sTILs) across different breast cancer grades and molecular subtypes, particularly their correlation with aggressive features.
• Conducted a comparative analysis of sTILs in various grades and molecular subtypes of breast carcinoma.
• Assessed correlation between sTIL levels and pathological features of the tumors.
• Evaluated the implications of standardized sTIL assessments on routine pathological reporting.
• sTILs show significant variability among breast cancer subtypes, especially noted in triple-negative breast cancer.
• High-grade tumors exhibit a stronger presence of sTILs compared to lower-grade ones.
• Incorporation of sTIL assessment in routine reporting could enhance identification of immune-active tumors.

Abstract