Measuring signatures of host resistance, disease tolerance, and damage in human sepsis: a prospective cohort study

Key Points

• This research aims to identify biomarker signatures related to host resistance and disease tolerance in sepsis.
• Conducted a prospective cohort study.
• Evaluated biomarker signatures informed by expert consensus.
• Examined associations with clinical outcomes and sepsis subtypes.
• Identified specific biomarker signatures associated with host resistance.
• Demonstrated links between biomarker profiles and clinical outcomes in sepsis.
• Found distinctions in biomarker signatures across different sepsis subtypes.

Abstract