Mechanosynthesis of cocrystals and coamorphous binary drug–drug systems with apremilast core: structural and biological studies

Key Points

• This research aims to understand how pharmaceutical binary systems form and ensure their safety in therapies.
• Analyzed mechanosynthesis techniques for cocrystals and coamorphous systems.
• Examined structural properties of drug-drug combinations.
• Conducted biological studies on the safety and efficacy of the systems.
• Identified successful formation techniques for stable binary systems.
• Observed enhanced drug interactions that may improve therapeutic outcomes.
• Found that certain combinations showed promising safety profiles.

Abstract