Dual Roles of CCN5/WISP2 in Cytosol and Secretome for Maintaining Muscle Homeostasis and Preventing Sarcopenia

Key Points

• The aim is to explore how CCN5 contributes to muscle homeostasis and prevents age-related muscle loss.
• Analyzed the effects of CCN5 on muscle cells
• Assessed mitochondrial function and interactions
• Investigated pathways related to myosteatosis
• CCN5 effectively reduces myosteatosis
• Promotes mitochondrial biogenesis
• Enhances interactions between lipid droplets and mitochondria

Abstract