What question did this study set out to answer?

This research aims to explore how childhood trauma affects working memory through frontoparietal network flexibility in schizophrenia.

April 10, 2026Open Access

Dynamic frontoparietal flexibility and cognitive dysfunction in schizophrenia: disentangling the roles of symptom burden and childhood trauma

Key Points

This research aims to explore how childhood trauma affects working memory through frontoparietal network flexibility in schizophrenia.
Examined the relationship between childhood trauma and cognitive performance in schizophrenia
Assessed frontoparietal network flexibility using neuroimaging techniques
Analyzed symptom burden to understand its impact on cognition
Frontoparietal network flexibility mediates the effect of childhood trauma on working memory
Higher trauma exposure correlates with increased cognitive dysfunction
Symptom burden influences cognitive performance in patients with schizophrenia

Abstract

Our findings highlight the central role of FPN flexibility in mediating childhood trauma's effect on working memory in schizophrenia. This outlines a key pathway through which an early environmental risk (trauma) translates into cognitive and clinical manifestations in schizophrenia.

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Discussion

Authors

Danqing Huang

Zhening Liu

Wenjian Tan

Journals

Psychological Medicine

Actions

Institutions

McGill University

Central South University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Dynamic frontoparietal flexibility and cognitive dysfunction in schizophrenia: disentangling the roles of symptom burden and childhood trauma

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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