Efficacy and Safety of Avacopan in ANCA-Associated Vasculitis: A Meta-Analysis of Randomized Controlled Trials

Key Points

• This research aims to evaluate the efficacy and safety of avacopan compared to glucocorticoid treatments in patients with ANCA-associated vasculitis.
• Conducted a meta-analysis of randomized controlled trials
• Compared effects of avacopan and glucocorticoid regimens
• Assessed outcomes related to disease remission and safety
• Avacopan showed higher efficacy in sustaining disease remission
• Significantly lower steroid-associated adverse effects observed with avacopan
• Indicated potential as a safer alternative to traditional therapies

Abstract